Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common variation in BRCA1 may have a role in progression to lethal prostate cancer after radiation treatment.

Prostate cancer and prostatic diseases - 1 Jun 2016

Sanchez A, Schoenfeld J D, Nguyen P L, Fiorentino M, Chowdhury D, Stampfer M J, Sesso H D, Giovannucci E, Mucci L A, Shui I M

Abstract excerpt

BACKGROUND: To evaluate whether single-nucleotide polymorphisms (SNPs) reflecting common variation in the tumor suppressor BRCA1 affect prostate cancer outcomes. Because radiation therapy (RT) induces DNA damage, we hypothesized that common variation in BRCA1 has a role in progression to lethal prostate cancer, particularly in patients receiving RT. METHODS: We followed 802 men diagnosed with localized prostate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Combined Modality Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Neoplasm Grading

Share to Neoplasm Metastasis

Share to Neoplasm Staging

Share to Proportional Hazards Models

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26926928
DOI: 10.1038/pcan.2016.4
PMCID: PMC4865401

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common variation in BRCA1 may have a role in progression to lethal prostate cancer after radiation treatment.PMID 26926928Read ↗

Common variation in the BRCA1 gene and prostate cancer risk.Semantic proximity Read ↗

Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types.Semantic proximity Read ↗

Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity.Semantic proximity Read ↗

Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study.Semantic proximity Read ↗

Confirmation of genetic variants associated with lethal prostate cancer in a cohort of men from hereditary prostate cancer families.Semantic proximity Read ↗

Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer.Semantic proximity Read ↗

No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity.Semantic proximity Read ↗

Genome-wide association study of prostate cancer mortality.Semantic proximity Read ↗

Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer.Semantic proximity Read ↗

PTBP1 Genetic Variants Affect the Clinical Response to Androgen-deprivation Therapy in Patients With Prostate Cancer.Semantic proximity Read ↗

Identifying Patients at Risk of Early Lethal Prostate Cancer by Integrating Family History, Polygenic Risk Score, Rare Variants in DNA Repair Genes, and Lifestyle Factors.Semantic proximity Read ↗

Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.