Article
Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 6 Jan 2025
Stopsack Konrad H, Vijai Joseph, Conry Michael, Berchuck Jacob E, Kemel Yelena, Vasselman Samantha E, Freeman Dory A, Lee Gwo-Shu M, Mandelker Diana, Solit David B, Morris Michael J, Penney Kathryn L, Abida Wassim, Offit Kenneth, Mucci Lorelei A, Kantoff Philip W, Pomerantz Mark M
Abstract excerpt
PURPOSE: Deleterious germline variants in certain DNA repair genes are risk factors for developing aggressive prostate cancer. The objective was to quantify their prognostic impact after prostate cancer diagnosis. EXPERIMENTAL DESIGN: Men with prostate cancer, predominantly of European ancestry, were included from four cohorts with long-term follow-up. Pathogenic or likely pathogenic germline variants in 26 DNA...
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