Article
Genome-wide association study of prostate cancer mortality.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2010
Penney Kathryn L, Pyne Saumyadipta, Schumacher Fredrick R, Sinnott Jennifer A, Mucci Lorelei A, Kraft Peter L, Ma Jing, Oh William K, Kurth Tobias, Kantoff Philip W, Giovannucci Edward L, Stampfer Meir J, Hunter David J, Freedman Matthew L
Abstract excerpt
BACKGROUND: A pressing clinical issue in prostate cancer is to distinguish which men will have an indolent or aggressive course of disease. Clinical variables such as Gleason grade and stage are useful predictors of lethal cancer; however, the low predictive values of the common Gleason scores, changes in grading over time, and earlier diagnosis of patients due to screening limits their clinical utility....
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