Article
Identifying Patients at Risk of Early Lethal Prostate Cancer by Integrating Family History, Polygenic Risk Score, Rare Variants in DNA Repair Genes, and Lifestyle Factors.
European urology oncology - 1 Apr 2026
Zhang Zhizhu, Zhang Yiwen, Stopsack Konrad H, Kibel Adam S, Giovannucci Edward L, Penney Kathryn L, Wang Anqi, Vijai Joseph, Kantoff Philip W, Pomerantz Mark M, Offit Kenneth, Mucci Lorelei A, Plym Anna
Abstract excerpt
BACKGROUND AND OBJECTIVE: In men with prostate cancer, one-third of deaths occur before the age of 75 yr. There remains a need to characterize heritable and environmental risk factors for these early deaths. This study aims to improve risk stratification for early lethal outcomes among prostate cancer patients with genetic factors beyond family history and with modifiable factors. METHODS: This study included 966...
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