No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity.

doi:10.1016/j.ijrobp.2022.06.098

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Article

No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity.

International journal of radiation oncology, biology, physics - 1 Nov 2022

Barnett Gillian C, Kerns Sarah L, Dorling Leila, Fachal Laura, Aguado-Barrera Miguel E, Martínez-Calvo Laura, Jandu Harkeran K, Welsh Ceilidh, Tyrer Jonathan, Coles Charlotte E, Haviland Joanne S, Parker Christopher, Gómez-Caamaño Antonio, Calvo-Crespo Patricia, Sosa-Fajardo Paloma, Burnet Neil G, Summersgill Holly, Webb Adam, De Ruysscher Dirk, Seibold Petra, Chang-Claude Jenny, Talbot Christopher J, Rattay Tim, Parliament Matthew, De Ruyck Kim, Rosenstein Barry S, Pharoah Paul D P, Dunning Alison M, Vega Ana, West Catharine M L

Abstract excerpt

PURPOSE: Our aim was to test whether updated polygenic risk scores (PRS) for susceptibility to cancer affect risk of radiation therapy toxicity. METHODS AND MATERIALS: Analyses included 9,717 patients with breast (n=3,078), prostate (n=5,748) or lung (n=891) cancer from Radiogenomics and REQUITE Consortia cohorts. Patients underwent potentially curative radiation therapy and were assessed prospectively for...

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Identifiers

PMID: 35840111
DOI: 10.1016/j.ijrobp.2022.06.098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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