Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer.

doi:10.1016/j.eururo.2014.10.022

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Article

Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer.

European urology - 1 Aug 2015

Castro Elena, Goh Chee, Leongamornlert Daniel, Saunders Ed, Tymrakiewicz Malgorzata, Dadaev Tokhir, Govindasami Koveela, Guy Michelle, Ellis Steve, Frost Debra, Bancroft Elizabeth, Cole Trevor, Tischkowitz Marc, Kennedy M John, Eason Jacqueline, Brewer Carole, Evans D Gareth, Davidson Rosemarie, Eccles Diana, Porteous Mary E, Douglas Fiona, Adlard Julian, Donaldson Alan, Antoniou Antonis C, Kote-Jarai Zsofia, Easton Douglas F, Olmos David, Eeles Rosalind

Abstract excerpt

BACKGROUND: Germline BRCA mutations are associated with worse prostate cancer (PCa) outcomes; however, the most appropriate management for mutation carriers has not yet been investigated. OBJECTIVE: To evaluate the response of BRCA carriers to conventional treatments for localised PCa by analysing metastasis-free survival (MFS) and cause-specific survival (CSS) following radical prostatectomy (RP) or...

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PMID: 25454609
DOI: 10.1016/j.eururo.2014.10.022

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