Article
Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types.
JNCI cancer spectrum - 31 Oct 2023
Naderi Elnaz, Aguado-Barrera Miguel E, Schack Line M H, Dorling Leila, Rattay Tim, Fachal Laura, Summersgill Holly, Martínez-Calvo Laura, Welsh Ceilidh, Dudding Tom, Odding Yasmin, Varela-Pazos Ana, Jena Rajesh, Thomson David J, Steenbakkers Roel J H M, Dennis Joe, Lobato-Busto Ramón, Alsner Jan, Ness Andy, Nutting Chris, Gómez-Caamaño Antonio, Eriksen Jesper G, Thomas Steve J, Bates Amy M, Webb Adam J, Choudhury Ananya, Rosenstein Barry S, Taboada-Valladares Begona, Herskind Carsten, Azria David, Dearnaley David P, de Ruysscher Dirk, Sperk Elena, Hall Emma, Stobart Hilary, Chang-Claude Jenny, De Ruyck Kim, Veldeman Liv, Altabas Manuel, De Santis Maria Carmen, Farcy-Jacquet Marie-Pierre, Veldwijk Marlon R, Sydes Matthew R, Parliament Matthew, Usmani Nawaid, Burnet Neil G, Seibold Petra, Symonds R Paul, Elliott Rebecca M, Bultijnck Renée, Gutiérrez-Enríquez Sara, Mollà Meritxell, Gulliford Sarah L, Green Sheryl, Rancati Tiziana, Reyes Victoria, Carballo Ana, Peleteiro Paula, Sosa-Fajardo Paloma, Parker Chris, Fonteyne Valérie, Johnson Kerstie, Lambrecht Maarten, Vanneste Ben, Valdagni Riccardo, Giraldo Alexandra, Ramos Mónica, Diergaarde Brenda, Liu Geoffrey, Leal Suzanne M, Chua Melvin L K, Pring Miranda, Overgaard Jens, Cascallar-Caneda Luis M, Duprez Fréderic, Talbot Christopher J, Barnett Gillian C, Dunning Alison M, Vega Ana, Andreassen Christian Nicolaj, Langendijk Johannes A, West Catharine M L, Alizadeh Behrooz Z, Kerns Sarah L
Abstract excerpt
BACKGROUND: This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). METHODS: A genome-wide association study meta-analysis was performed using 19 cohorts totaling 12 042 patients. Acute standardized total average toxicity (STATacute) was modelled using a...