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Article

The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Montesanto Alberto, Crocco Paolina, Anfossi Maria, Smirne Nicoletta, Puccio Gianfranco, Colao Rosanna, Maletta Raffaele, Passarino Giuseppe, Bruni Amalia C, Rose Giuseppina

Abstract excerpt

Uncoupling proteins (UCPs) are a group of five mitochondrial inner membrane transporters with a tissue specific expression that uncouple biofuel oxidation from ATP synthesis and function as regulators of energy homeostasis and antioxidants. Previous data suggested that neuronal UCPs (UCP2, UCP4, and UCP5) can directly influence synaptic plasticity, neurotransmission, and neurodegenerative processes, and have a...

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Identifiers

PMID: 26923023
DOI: 10.3233/JAD-150993

Genes

APOE
UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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