Article
Association of GWAS Top Genes With Late-Onset Alzheimer's Disease in Colombian Population.
American journal of Alzheimer's disease and other dementias - 1 Feb 2017
Moreno Diana Jennifer, Ruiz Susana, Ríos Ángela, Lopera Francisco, Ostos Henry, Via Marc, Bedoya Gabriel
Abstract excerpt
OBJECTIVE: The association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer's disease (LOAD) was evaluated and confirmed through genome-wide association study. However, it is unknown whether these associations can be replicated in admixed populations. METHODS: The association of 14 single-nucleotide polymorphisms in those genes was evaluated in 280 LOAD cases and 357 controls...
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