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Article

Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.

PloS one - 1 Jan 2011

Rose Giuseppina, Crocco Paolina, De Rango Francesco, Montesanto Alberto, Passarino Giuseppe

Abstract excerpt

In humans Uncoupling Proteins (UCPs) are a group of five mitochondrial inner membrane transporters with variable tissue expression, which seem to function as regulators of energy homeostasis and antioxidants. In particular, these proteins uncouple respiration from ATP production, allowing stored energy to be released as heat. Data from experimental models have previously suggested that UCPs may play an important...

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Source

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Identifiers

PMID: 22216339
DOI: 10.1371/journal.pone.0029650
PMCID: PMC3246500

Genes

UCP2
UCP3

Provenance

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Related research

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Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.PMID 22216339Read ↗

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Semantic proximity Read ↗

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.Semantic proximity Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians.Semantic proximity Read ↗

The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.Semantic proximity Read ↗

Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis.Semantic proximity Read ↗

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.Semantic proximity Read ↗

Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females.Semantic proximity Read ↗

New aspects of mitochondrial Uncoupling Proteins (UCPs) and their roles in tumorigenesis.Semantic proximity Read ↗

Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity.Semantic proximity Read ↗

Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsideredSemantic proximity Read ↗

Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance.Semantic proximity Read ↗

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