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Article

epiGBS: reference-free reduced representation bisulfite sequencing.

Nature methods - 1 Apr 2016

van Gurp Thomas P, Wagemaker Niels C A M, Wouters Björn, Vergeer Philippine, Ouborg Joop N J, Verhoeven Koen J F

Abstract excerpt

We describe epiGBS, a reduced representation bisulfite sequencing method for cost-effective exploration and comparative analysis of DNA methylation and genetic variation in hundreds of samples de novo. This method uses genotyping by sequencing of bisulfite-converted DNA followed by reliable de novo reference construction, mapping, variant calling, and distinction of single-nucleotide polymorphisms (SNPs) versus...

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Share to DNA Methylation
Share to Epigenesis, Genetic
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, DNA

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Identifiers

PMID: 26855363
DOI: 10.1038/nmeth.3763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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