Article

Differential methylation analysis of reduced representation bisulfite sequencing experiments using edgeR

2018-10-08

Abstract excerpt

Cytosine methylation is an important DNA epigenetic modification. In vertebrates, methylation occurs at CpG sites, which are dinucleotides where a cytosine is immediately followed by a guanine in the DNA sequence from 5' to 3'. When located in the promoter region of a gene, DNA methylation is often associated with transcriptional silencing of the gene. Aberrant DNA methylation is associated with the development of...

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Literature Corpus work: 30bbdd65-7b27-526a-b189-2860d4bc824e
DOI: 10.12688/f1000research.13196.2

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