Article
CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data.
Bioinformatics (Oxford, England) - 1 Feb 2018
Guo Weilong, Zhu Ping, Pellegrini Matteo, Zhang Michael Q, Wang Xiangfeng, Ni Zhongfu
Abstract excerpt
Motivation: DNA methylation is important for gene silencing and imprinting in both plants and animals. Recent advances in bisulfite sequencing allow detection of single nucleotide variations (SNVs) achieving high sensitivity, but accurately identifying heterozygous SNVs from partially C-to-T converted sequences remains challenging. Results: We designed two methods, BayesWC and BinomWC, that substantially improved...
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