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Article

Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2015

Adams Hieab H H, de Bruijn Renée F A G, Hofman Albert, Uitterlinden André G, van Duijn Cornelia M, Vernooij Meike W, Koudstaal Peter J, Ikram M Arfan

Abstract excerpt

INTRODUCTION: Neurodegenerative diseases are a major cause of cognitive impairment and can ultimately lead to dementia. Genome-wide association studies have uncovered many genetic variants conferring risk of neurodegenerative diseases, but their role in cognitive impairment remains unexplored. METHODS: In the prospective, population-based Rotterdam Study, 3605 nondemented persons aged ≥55 years were genotyped,...

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Identifiers

PMID: 25916564
DOI: 10.1016/j.jalz.2014.12.008

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