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Article

Staufen Negatively Modulates MicroRNA Activity in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 3 May 2016

Ren Zhiji, Veksler-Lublinsky Isana, Morrissey David, Ambros Victor

Abstract excerpt

The double-stranded RNA-binding protein Staufen has been implicated in various posttranscriptional gene regulatory processes. Here, we demonstrate that the Caenorhabditis elegans homolog of Staufen, STAU-1, functionally interacts with microRNAs. Loss-of-function mutations of stau-1 significantly suppress phenotypes of let-7 family microRNA mutants, a hypomorphic allele of dicer, and a lsy-6 microRNA partial...

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Identifiers

PMID: 26921297
DOI: 10.1534/g3.116.027300
PMCID: PMC4856075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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