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Article

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

Nature - 12 Feb 2004

Kennedy Scott, Wang Duo, Ruvkun Gary

Abstract excerpt

In many organisms, introducing double-stranded RNA (dsRNA) causes the degradation of messenger RNA that is homologous to the trigger dsRNA--a process known as RNA interference. The dsRNA is cleaved into short interfering RNAs (siRNAs), which hybridize to homologous mRNAs and induce their degradation. dsRNAs vary in their ability to trigger RNA interference: many mRNA-targeting dsRNAs show weak phenotypes, and...

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PMID: 14961122
DOI: 10.1038/nature02302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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