Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.

Genome biology - 1 Jan 2006

Lehner Ben, Calixto Andrea, Crombie Catriona, Tischler Julia, Fortunato Angelo, Chalfie Martin, Fraser Andrew G

Abstract excerpt

BACKGROUND: Genome-wide RNA interference (RNAi) screening is a very powerful tool for analyzing gene function in vivo in Caenorhabditis elegans. The effectiveness of RNAi varies from gene to gene, however, and neuronally expressed genes are largely refractive to RNAi in wild-type worms. RESULTS: We found that C. elegans strains carrying mutations in lin-35, the worm ortholog of the tumor suppressor gene p105Rb,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Gene Silencing

Share to Genes, Helminth

Share to Nervous System

Share to Retinoblastoma Protein

Share to Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 16507136
DOI: 10.1186/gb-2006-7-1-r4
PMCID: PMC1431716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.PMID 16507136Read ↗

Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.Semantic proximity Read ↗

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read ↗

Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.Semantic proximity Read ↗

A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans.Semantic proximity Read ↗

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.Semantic proximity Read ↗

lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development.Semantic proximity Read ↗

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.Semantic proximity Read ↗

LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.Semantic proximity Read ↗

Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.Semantic proximity Read ↗

The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans.Semantic proximity Read ↗

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.