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Article

Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.

PLoS genetics - 1 Jan 2013

Hunter Shaun E, Finnegan Emily F, Zisoulis Dimitrios G, Lovci Michael T, Melnik-Martinez Katya V, Yeo Gene W, Pasquinelli Amy E

Abstract excerpt

The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigenesis. These defects are due to improper expression of protein-coding genes normally under let-7 regulation. While some direct targets of let-7 have been identified,...

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Identifiers

PMID: 23516374
DOI: 10.1371/journal.pgen.1003353
PMCID: PMC3597506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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