Article
TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.
Nucleic acids research - 17 Feb 2017
Wang Chris, Gupta Pratyush, Fressigne Lucile, Bossé Gabriel D, Wang Xin, Simard Martin J, Hansen Dave
Abstract excerpt
MiRNAs post-transcriptionally regulate gene expression by recruiting the miRNA-induced silencing complex (miRISC) to target mRNAs. However, the mechanisms by which miRISC components are maintained at appropriate levels for proper function are largely unknown. Here, we demonstrate that Caenorhabditis elegans TEG-1 regulates the stability of two miRISC effectors, VIG-1 and ALG-1, which in turn affects the abundance...
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