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Article

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Acta neuropathologica communications - 25 Feb 2016

Knight Elysse M, Ruiz Henry H, Kim Soong Ho, Harte Jessica C, Hsieh Wilson, Glabe Charles, Klein William L, Attie Alan D, Buettner Christoph, Ehrlich Michelle E, Gandy Sam

Abstract excerpt

INTRODUCTION: Insulin resistance and type 2 diabetes mellitus (T2D) are associated with increased risk for cognitive impairment, Alzheimer's disease (AD) and vascular dementia. SORCS1 encodes a protein-sorting molecule genetically linked to both T2D and AD. The association of SORCS1 with both AD and T2D is sexually dimorphic in humans, with both disease associations showing more robust effects in females. Based...

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Source

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Identifiers

PMID: 26916443
DOI: 10.1186/s40478-016-0282-y
PMCID: PMC4766719

Genes

APP
PSEN1
SORCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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