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Article

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.

The Journal of clinical investigation - 1 Oct 2014

Kebede Melkam A, Oler Angie T, Gregg Trillian, Balloon Allison J, Johnson Adam, Mitok Kelly, Rabaglia Mary, Schueler Kathryn, Stapleton Donald, Thorstenson Candice, Wrighton Lindsay, Floyd Brendan J, Richards Oliver, Raines Summer, Eliceiri Kevin, Seidah Nabil G, Rhodes Christopher, Keller Mark P, Coon Joshua L, Audhya Anjon, Attie Alan D

Abstract excerpt

We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus. Sorcs1 belongs to the Vacuolar protein sorting-10 (Vps10) gene family. In yeast, Vps10 transports enzymes from the trans-Golgi network (TGN) to the vacuole. Whole-body Sorcs1 KO mice, when made obese with the leptin(ob) mutation (ob/ob), developed diabetes. β Cells from these mice had a severe deficiency of secretory granules (SGs)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25157818
DOI: 10.1172/JCI74072
PMCID: PMC4191024

Genes

SORCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.PMID 25157818Read ↗

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.Semantic proximity Read ↗

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretionSemantic proximity Read ↗

Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells.Semantic proximity Read ↗

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.Semantic proximity Read ↗

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivitySemantic proximity Read ↗

Sorting receptor SORCS2 facilitates a protective stress response in pancreatic isletsSemantic proximity Read ↗

RNA-sequencing of WFS1-deficient pancreatic islets.Semantic proximity Read ↗

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivitySemantic proximity Read ↗

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.Semantic proximity Read ↗

β-cell NCK1 is reduced in type 2 diabetes, leading to inefficient β-cell UPR and insulin secretion and revealing sex-specific adaptation during metabolic stressSemantic proximity Read ↗

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.Semantic proximity Read ↗

Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes.Semantic proximity Read ↗

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