BACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice.

doi:10.1016/j.nbd.2023.106142

Back to search

Article

BACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice.

Neurobiology of disease - 15 Jun 2023

Franklin Z J, Croce L, Dekeryte R, Delibegovic M, Platt B

Abstract excerpt

BACKGROUND: Alzheimer's Disease (AD) and Type 2 Diabetes Mellitus (T2DM), two prevalent diseases related to ageing, often share common pathologies including increased inflammation, endoplasmic reticulum (ER) stress, and impaired metabolic homeostasis predominantly affecting different organs. Ther...

Topics

Mice
Male
Animals
Amyloid beta-Protein Precursor
Dipeptidyl Peptidase 4
Diabetes Mellitus, Type 2
Mice, Transgenic
Endoribonucleases
Protein Serine-Threonine Kinases
Alzheimer Disease
Phenotype
Amyloid beta-Peptides
Amyloid Precursor Protein Secretases

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.