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Article

BACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice.

Neurobiology of disease - 15 Jun 2023

Franklin Z J, Croce L, Dekeryte R, Delibegovic M, Platt B

Abstract excerpt

BACKGROUND: Alzheimer's Disease (AD) and Type 2 Diabetes Mellitus (T2DM), two prevalent diseases related to ageing, often share common pathologies including increased inflammation, endoplasmic reticulum (ER) stress, and impaired metabolic homeostasis predominantly affecting different organs. Therefore, it was unexpected to find in a previous study that neuronal hBACE1 knock-in (PLB4 mouse) leads to both an AD-...

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Identifiers

PMID: 37137417
DOI: 10.1016/j.nbd.2023.106142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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