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Article

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Sept 2010

Lane Rachel F, Raines Summer M, Steele John W, Ehrlich Michelle E, Lah James A, Small Scott A, Tanzi Rudolph E, Attie Alan D, Gandy Sam

Abstract excerpt

SorCS1 and SorL1/SorLA/LR11 belong to the sortilin family of vacuolar protein sorting-10 (Vps10) domain-containing proteins. Both are genetically associated with Alzheimer's disease (AD), and SORL1 expression is decreased in the brains of patients suffering from AD. SORCS1 is also genetically associated with types 1 and 2 diabetes mellitus (T1DM, T2DM). We have undertaken a study of the possible role(s) for...

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Identifiers

PMID: 20881129
DOI: 10.1523/JNEUROSCI.3872-10.2010
PMCID: PMC3274732

Genes

APP
SORCS1
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.PMID 20881129Read ↗

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