Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.

doi:10.1111/j.1582-4934.2011.01384.x

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Article

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.

Journal of cellular and molecular medicine - 1 Jun 2012

Hiltunen Mikko, Khandelwal Vinoth K M, Yaluri Nagendra, Tiilikainen Tea, Tusa Maija, Koivisto Henna, Krzisch Marine, Vepsäläinen Saila, Mäkinen Petra, Kemppainen Susanna, Miettinen Pasi, Haapasalo Annakaisa, Soininen Hilkka, Laakso Markku, Tanila Heikki

Abstract excerpt

According to epidemiological studies, type-2 diabetes increases the risk of Alzheimer's disease. Here, we induced hyperglycaemia in mice overexpressing mutant amyloid precursor protein and presenilin-1 (APdE9) either by cross-breeding them with pancreatic insulin-like growth factor 2 (IGF-2) over...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Blotting, Western
Brain
Cerebral Cortex
Diet, High-Fat
Female
Glucose Tolerance Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycogen Synthase Kinase 3

Glycogen Synthase Kinase 3 beta

Hybridization, Genetic

Hyperglycemia

Insulin

Insulin Resistance

Insulin-Like Growth Factor II

Male

Source

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Identifiers

PMID: 21762376
DOI: 10.1111/j.1582-4934.2011.01384.x
PMCID: PMC3823075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21762376-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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