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Article

Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.

The Journal of clinical endocrinology and metabolism - 1 Oct 2012

Hsu Yi-Hsiang, Kiel Douglas P

Abstract excerpt

CONTEXT: The primary goals of genome-wide association studies (GWAS) are to discover new molecular and biological pathways involved in the regulation of bone metabolism that can be leveraged for drug development. In addition, the identified genetic determinants may be used to enhance current risk factor profiles. EVIDENCE ACQUISITION: There have been more than 40 published GWAS on skeletal phenotypes,...

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PMID: 22965941
DOI: 10.1210/jc.2012-1890
PMCID: PMC3674343

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