Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women.

doi:10.1002/jbmr.1796

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Article

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2013

Koller Daniel L, Zheng Hou-Feng, Karasik David, Yerges-Armstrong Laura, Liu Ching-Ti, McGuigan Fiona, Kemp John P, Giroux Sylvie, Lai Dongbing, Edenberg Howard J, Peacock Munro, Czerwinski Stefan A, Choh Audrey C, McMahon George, St Pourcain Beate, Timpson Nicholas J, Lawlor Debbie A, Evans David M, Towne Bradford, Blangero John, Carless Melanie A, Kammerer Candace, Goltzman David, Kovacs Christopher S, Prior Jerilynn C, Spector Tim D, Rousseau Francois, Tobias Jon H, Akesson Kristina, Econs Michael J, Mitchell Braxton D, Richards J Brent, Kiel Douglas P, Foroud Tatiana

Abstract excerpt

Previous genome-wide association studies (GWAS) have identified common variants in genes associated with variation in bone mineral density (BMD), although most have been carried out in combined samples of older women and men. Meta-analyses of these results have identified numerous single-nucleotide polymorphisms (SNPs) of modest effect at genome-wide significance levels in genes involved in both bone formation...

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PMID: 23074152
DOI: 10.1002/jbmr.1796
PMCID: PMC3691010

Genes

ESR1
WNT16

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