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Article

Integration of summary data from GWAS and eQTL studies identified novel causal BMD genes with functional predictions.

Bone - 1 Aug 2018

Meng Xiang-He, Chen Xiang-Ding, Greenbaum Jonathan, Zeng Qin, You Sheng-Lan, Xiao Hong-Mei, Tan Li-Jun, Deng Hong-Wen

Abstract excerpt

PURPOSE: Osteoporosis is a common global health problem characterized by low bone mineral density (BMD) and increased risk of fracture. Genome-wide association studies (GWAS) have identified >100 genetic loci associated with BMD. However, the functional genes responsible for most associations remain largely unknown. We conducted an innovative summary statistic data-based Mendelian randomization (SMR) analysis to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29763751
DOI: 10.1016/j.bone.2018.05.012
PMCID: PMC6346739

Genes

SYN2
ALPL
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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