Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.

doi:10.1093/hmg/ddw289

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.

Human molecular genetics - 1 Dec 2016

Hsu Yi-Hsiang, Li Guo, Liu Ching-Ti, Brody Jennifer A, Karasik David, Chou Wen-Chi, Demissie Serkalem, Nandakumar Kannabiran, Zhou Yanhua, Cheng Chia-Ho, Gill Richard, Gibbs Richard A, Muzny Donna, Santibanez Jireh, Estrada Karol, Rivadeneira Fernando, Harris Tamara, Gudnason Vilmundur, Uitterlinden Andre, Psaty Bruce M, Robbins John A, Adrienne Cupples L, Kiel Douglas P

Abstract excerpt

Background: Bone mineral density (BMD) is a heritable phenotype that predicts fracture risk. We performed fine-mapping by targeted sequencing at WLS, MEF2C, ARHGAP1/F2 and JAG1 loci prioritized by eQTL and bioinformatic approaches among 56 BMD loci from our previous GWAS meta-analysis. Targeted sequencing was conducted in 1,291 Caucasians from the Framingham Heart Study ( n = 925) and Cardiovascular Health Study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Density

Share to Cardiovascular Diseases

Share to Cohort Studies

Share to Epidemiologic Studies

Share to Femur Neck

Share to GTPase-Activating Proteins

Share to MEF2 Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27616567
DOI: 10.1093/hmg/ddw289
PMCID: PMC5837042

Genes

ARHGAP1
WLS
F2
JAG1
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.PMID 27616567Read ↗

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.Semantic proximity Read ↗

A multiethnic whole genome sequencing study to identify novel loci for bone mineral density.Semantic proximity Read ↗

Exome-wide screening identifies novel rare risk variants for bone mineral density.Semantic proximity Read ↗

Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.Semantic proximity Read ↗

Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk.Semantic proximity Read ↗

Genomic structural variations link multiple genes to bone mineral density in a multi-ethnic cohort study: Louisiana osteoporosis studySemantic proximity Read ↗

An Atlas of Human and Murine Genetic Influences on OsteoporosisSemantic proximity Read ↗

A Statistical Approach to Fine Mapping for the Identification of Potential Causal Variants Related to Bone Mineral Density.Semantic proximity Read ↗

Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.Semantic proximity Read ↗

Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.Semantic proximity Read ↗

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.Semantic proximity Read ↗

Genome-wide association study of lncRNA polymorphisms with bone mineral density.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.