Article
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
Nature genetics - 1 Nov 2009
Rivadeneira Fernando, Styrkársdottir Unnur, Estrada Karol, Halldórsson Bjarni V, Hsu Yi-Hsiang, Richards J Brent, Zillikens M Carola, Kavvoura Fotini K, Amin Najaf, Aulchenko Yurii S, Cupples L Adrienne, Deloukas Panagiotis, Demissie Serkalem, Grundberg Elin, Hofman Albert, Kong Augustine, Karasik David, van Meurs Joyce B, Oostra Ben, Pastinen Tomi, Pols Huibert A P, Sigurdsson Gunnar, Soranzo Nicole, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Williams Frances M K, Wilson Scott G, Zhou Yanhua, Ralston Stuart H, van Duijn Cornelia M, Spector Timothy, Kiel Douglas P, Stefansson Kari, Ioannidis John P A, Uitterlinden André G
Abstract excerpt
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 x 10(-8)), of which 13 map to regions not...
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