Article
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
Human molecular genetics - 1 Apr 2014
Zhang Lei, Choi Hyung Jin, Estrada Karol, Leo Paul J, Li Jian, Pei Yu-Fang, Zhang Yinping, Lin Yong, Shen Hui, Liu Yao-Zhong, Liu Yongjun, Zhao Yingchun, Zhang Ji-Gang, Tian Qing, Wang Yu-ping, Han Yingying, Ran Shu, Hai Rong, Zhu Xue-Zhen, Wu Shuyan, Yan Han, Liu Xiaogang, Yang Tie-Lin, Guo Yan, Zhang Feng, Guo Yan-fang, Chen Yuan, Chen Xiangding, Tan Lijun, Zhang Lishu, Deng Fei-Yan, Deng Hongyi, Rivadeneira Fernando, Duncan Emma L, Lee Jong Young, Han Bok Ghee, Cho Nam H, Nicholson Geoffrey C, McCloskey Eugene, Eastell Richard, Prince Richard L, Eisman John A, Jones Graeme, Reid Ian R, Sambrook Philip N, Dennison Elaine M, Danoy Patrick, Yerges-Armstrong Laura M, Streeten Elizabeth A, Hu Tian, Xiang Shuanglin, Papasian Christopher J, Brown Matthew A, Shin Chan Soo, Uitterlinden André G, Deng Hong-Wen
Abstract excerpt
Aiming to identify novel genetic variants and to confirm previously identified genetic variants associated with bone mineral density (BMD), we conducted a three-stage genome-wide association (GWA) meta-analysis in 27 061 study subjects. Stage 1 meta-analyzed seven GWA samples and 11 140 subjects for BMDs at the lumbar spine, hip and femoral neck, followed by a Stage 2 in silico replication of 33 SNPs in 9258...
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