Article
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
PLoS genetics - 10 Jun 2010
Hsu Yi-Hsiang, Zillikens M Carola, Wilson Scott G, Farber Charles R, Demissie Serkalem, Soranzo Nicole, Bianchi Estelle N, Grundberg Elin, Liang Liming, Richards J Brent, Estrada Karol, Zhou Yanhua, van Nas Atila, Moffatt Miriam F, Zhai Guangju, Hofman Albert, van Meurs Joyce B, Pols Huibert A P, Price Roger I, Nilsson Olle, Pastinen Tomi, Cupples L Adrienne, Lusis Aldons J, Schadt Eric E, Ferrari Serge, Uitterlinden André G, Rivadeneira Fernando, Spector Timothy D, Karasik David, Kiel Douglas P
Abstract excerpt
Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic variants identified so far only explain a small proportion of the heritability for complex traits. Due to the modest genetic effect size and inadequate power, true...
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