Genome-Wide Linkage Screen of Bone Mineral Density (BMD) in European Pedigrees Ascertained through a Male Relative with Low BMD Values: Evidence for Quantitative Trait Loci on 17q21–23, 11q12–13, 13q12–14, and 22q11

Abstract excerpt

CONTEXT: Bone mass is under strong genetic control, with heritability estimates greater than 50% and is likely determined by complex interactions between genetic and environmental factors. OBJECTIVE: The objective of the study was to localize genes contributing to bone mineral density (BMD) variation. DESIGN: An autosomal genome-wide scan for BMD at the lumbar spine and femoral neck was conducted with variance...

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