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Article

Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.

Archives of biochemistry and biophysics - 1 Jul 2016

Huang Wenrui, Kazmierczak Katarzyna, Zhou Zhiqun, Aguiar-Pulido Vanessa, Narasimhan Giri, Szczesna-Cordary Danuta

Abstract excerpt

Using microarray and bioinformatics, we examined the gene expression profiles in transgenic mouse hearts expressing mutations in the myosin regulatory light chain shown to cause hypertrophic cardiomyopathy (HCM). We focused on two malignant RLC-mutations, Arginine 58→Glutamine (R58Q) and Aspartic Acid 166 → Valine (D166V), and one benign, Lysine 104 → Glutamic Acid (K104E)-mutation. Datasets of differentially...

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Identifiers

PMID: 26906074
DOI: 10.1016/j.abb.2016.02.022
PMCID: PMC5370580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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