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Article

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion.

Journal of molecular and cellular cardiology - 1 Aug 2018

Ehsan Mehroz, Kelly Matthew, Hooper Charlotte, Yavari Arash, Beglov Julia, Bellahcene Mohamed, Ghataorhe Kirandeep, Poloni Giulia, Goel Anuj, Kyriakou Theodosios, Fleischanderl Karin, Ehler Elisabeth, Makeyev Eugene, Lange Stephan, Ashrafian Houman, Redwood Charles, Davies Benjamin, Watkins Hugh, Gehmlich Katja

Abstract excerpt

Cysteine and glycine rich protein 3 (CSRP3) encodes Muscle LIM Protein (MLP), a well-established disease gene for Hypertrophic Cardiomyopathy (HCM). MLP, in contrast to the proteins encoded by the other recognised HCM disease genes, is non-sarcomeric, and has important signalling functions in cardiomyocytes. To gain insight into the disease mechanisms involved, we generated a knock-in mouse (KI) model, carrying...

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Source

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Identifiers

PMID: 30048712
DOI: 10.1016/j.yjmcc.2018.07.248
PMCID: PMC6117453

Genes

CSRP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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