Article
Gene expression profile in dilated cardiomyopathy caused by elevated frequencies of mitochondrial DNA mutations in the mouse heart.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000
Zhang Dekui, Ezekiel Uthayashanker R, Chang Shin-Wen, Zassenhaus Hans Peter
Abstract excerpt
BACKGROUND: Elevated mitochondrial DNA (mtDNA) mutations are associated with aging and age-related diseases, but their pathogenic potential is unclear. METHODS: We performed expression profiling using an Incyte cDNA array of a mouse model of elevated mtDNA mutations wherein random mutations accum...
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