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Article

Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.

Physiological genomics - 13 Mar 2006

Mitchell Scherise, Ota Asuka, Foster William, Zhang Bin, Fang Zixing, Patel Shilpa, Nelson Stanley F, Horvath Steve, Wang Yibin

Abstract excerpt

Three major MAP kinase signaling cascades, ERK, p38, and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. To study the specific function of each MAP kinase branch in adult heart, we have generated three transgenic mouse models with cardiac-specific and temporally regulated expression of activated mutants of Ras, MAP...

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Source

Identifiers

PMID: 16368875
DOI: 10.1152/physiolgenomics.00224.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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