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Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy

2 Aug 2006

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is a disease characterized by ventricular hypertrophy, fibrosis, and aberrant systolic and/or diastolic function. We previously developed two transgenic mouse models that carry FHC-associated mutations in alpha-tropomyosin (TM): FHC alpha-TM175 mice show patchy areas of mild ventricular disorganization and limited hypertrophy, whereas FHC alpha-TM180 mice exhibit severe...

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PMID: 16882888
DOI: 10.1152/physiolgenomics.00072.2006

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