Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China.

Antimicrobial agents and chemotherapy - 1 May 2016

Li Qin-Jing, Jiao Wei-Wei, Yin Qing-Qin, Xu Fang, Li Jie-Qiong, Sun Lin, Xiao Jing, Li Ying-Jia, Mokrousov Igor, Huang Hai-Rong, Shen A-Dong

Abstract excerpt

Mycobacterium tuberculosis can acquire resistance to rifampin (RIF) through mutations in the rpoB gene. This is usually accompanied by a fitness cost, which, however, can be mitigated by secondary mutations in the rpoA or rpoC gene. This study aimed to identify rpoA and rpoC mutations in clinical M. tuberculosis isolates in northern China in order to clarify their role in the transmission of drug-resistant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to China

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Genotype

Share to Microbial Sensitivity Tests

Share to Mycobacterium tuberculosis

Share to Rifampin

Share to Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 26902762
DOI: 10.1128/AAC.02358-15
PMCID: PMC4862491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China.PMID 26902762Read ↗

Characteristics of compensatory mutations in the rpoC gene and their association with compensated transmission of Mycobacterium tuberculosis.Semantic proximity Read ↗

A 10-Year Comparative Analysis Shows that Increasing Prevalence of Rifampin-Resistant Mycobacterium tuberculosis in China Is Associated with the Transmission of Strains Harboring Compensatory Mutations.Semantic proximity Read ↗

Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains.Semantic proximity Read ↗

Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China.Semantic proximity Read ↗

Novel and Reported Compensatory Mutations in <i>rpoABC</i> Associate Specifically with Predominant <i>Mycobacterium tuberculosis</i> Rifampicin Resistance Marker <i>rpoB</i> :S450LSemantic proximity Read ↗

Evaluation of the frequency of mutation genes in multidrug-resistant tuberculosis (MDR-TB) strains in Beijing, China.Semantic proximity Read ↗

Putative compensatory mutations in the rpoC gene of rifampin-resistant Mycobacterium tuberculosis are associated with ongoing transmission.Semantic proximity Read ↗

Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?Semantic proximity Read ↗

Comparison on Major Gene Mutations Related to Rifampicin and Isoniazid Resistance between Beijing and Non-Beijing Strains of Mycobacterium tuberculosis: A Systematic Review and Bayesian Meta-Analysis.Semantic proximity Read ↗

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region.Semantic proximity Read ↗

Characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Sichuan in China.Semantic proximity Read ↗

Rifampin resistance-associated mutations in the RIF resistance-determining region (RRDR) of the rpoB gene of Mycobacterium tuberculosis clinical isolates in Shanghai, ChinaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.