Article
Putative compensatory mutations in the rpoC gene of rifampin-resistant Mycobacterium tuberculosis are associated with ongoing transmission.
Antimicrobial agents and chemotherapy - 1 Feb 2013
de Vos M, Müller B, Borrell S, Black P A, van Helden P D, Warren R M, Gagneux S, Victor T C
Abstract excerpt
Rifampin resistance in clinical isolates of Mycobacterium tuberculosis arises primarily through the selection of bacterial variants harboring mutations in the 81-bp rifampin resistance-determining region of the rpoB gene. While these mutations were shown to infer a fitness cost in the absence of antibiotic pressure, compensatory mutations in rpoA and rpoC were identified which restore the fitness of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.