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Article

Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China.

BMC microbiology - 6 Oct 2025

Che Yang, Li Xiangchen, Zhang Dongliang, Sang Guoxin, Gao Junli, Gao Junshun, Lu Yewei, Liu Zhengwei

Abstract excerpt

BACKGROUND: The global spread of rifampicin-resistant tuberculosis (RR-TB) presents a significant challenge to tuberculosis control, with compensatory mutations hypothesized to offset the fitness cost of drug resistance, thereby facilitating transmission. However, the characteristics and epidemiological impact of these mutations in coastal regions of Eastern China remain inadequately understood. This study aimed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41053587
DOI: 10.1186/s12866-025-04390-w
PMCID: PMC12502504

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