Article
Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains.
International journal of antimicrobial agents - 1 Jun 2017
Li Qin-Jing, Jiao Wei-Wei, Yin Qing-Qin, Li Ying-Jia, Li Jie-Qiong, Xu Fang, Sun Lin, Xiao Jing, Qi Hui, Wang Ting, Mokrousov Igor, Huang Hai-Rong, Shen A-Dong
Abstract excerpt
Mycobacterium tuberculosis Beijing genotype strains increasingly circulate in different world regions, either as historical endemic, e.g. in East Asia, or recently imported, e.g. in South America, and this family is regarded as the most successful lineage of the global tuberculosis (TB) epidemic. Here we analysed the transmission capacity of these strains in the context of their phylogenetic background and drug...
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