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Article

RNA helicase Belle/DDX3 regulates transgene expression in Drosophila.

Developmental biology - 1 Apr 2016

Lo Pang-Kuo, Huang Yi-Chun, Poulton John S, Leake Nicholas, Palmer William H, Vera Daniel, Xie Gengqiang, Klusza Stephen, Deng Wu-Min

Abstract excerpt

Belle (Bel), the Drosophila homolog of the yeast DEAD-box RNA helicase DED1 and human DDX3, has been shown to be required for oogenesis and female fertility. Here we report a novel role of Bel in regulating the expression of transgenes. Abrogation of Bel by mutations or RNAi induces silencing of a variety of P-element-derived transgenes. This silencing effect depends on downregulation of their RNA levels. Our...

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Identifiers

PMID: 26900887
DOI: 10.1016/j.ydbio.2016.02.014
PMCID: PMC4814335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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