Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ddx1 knockout results in transgenerational wild-type lethality in mice.

Scientific reports - 24 Apr 2015

Hildebrandt Matthew R, Germain Devon R, Monckton Elizabeth A, Brun Miranda, Godbout Roseline

Abstract excerpt

DEAD box 1 (DDX1) is a member of the DEAD box family of RNA helicases which are involved in all aspects of RNA metabolism. DDX1 has been implicated in a variety of biological processes, including 3'-end processing of mRNA, DNA repair, microRNA processing, tRNA maturation and mRNA transport. To study the role of DDX1 during development, we have generated mice carrying a constitutive Ddx1 knock-out allele....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DEAD-box RNA Helicases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Heterozygote

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 25909345
DOI: 10.1038/srep09829
PMCID: PMC4408975

Genes

DDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ddx1 knockout results in transgenerational wild-type lethality in mice.PMID 25909345Read ↗

DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in miceSemantic proximity Read ↗

Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis.Semantic proximity Read ↗

DDX41 is needed for pre-and post-natal hematopoietic stem cell differentiation in miceSemantic proximity Read ↗

The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.Semantic proximity Read ↗

EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Semantic proximity Read ↗

The DEAD box RNA helicase Ddx39a is essential for myocyte and lens development in zebrafishSemantic proximity Read ↗

Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice.Semantic proximity Read ↗

The QxxR Motif of RNA Helicase Me31B Is Essential for Drosophila Female Fertility and Germline DevelopmentSemantic proximity Read ↗

The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish.Semantic proximity Read ↗

The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders.Semantic proximity Read ↗

DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy.Semantic proximity Read ↗

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.