Drosophila damaged DNA-binding protein 1 is an essential factor for development.

doi:10.1534/genetics.103.025965

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Article

Drosophila damaged DNA-binding protein 1 is an essential factor for development.

Genetics - 1 Oct 2004

Takata Kei-ichi, Yoshida Hideki, Yamaguchi Masamitsu, Sakaguchi Kengo

Abstract excerpt

The damaged DNA-binding protein (DDB) complex, thought to recognize (6-4) photoproducts and other lesions in DNA, has been implicated to have a role in global genomic nucleotide excision repair (NER) and E2F-1-mediated transcription. The complex consists of a heterodimer of p127 (DDB1) and p48 (DDB2), the latter also being known as XPE. We reported previously that in Drosophila expression of the DDB1 (D-DDB1)...

Topics

Animals
Animals, Genetically Modified
Apoptosis
Bromodeoxyuridine
DNA Repair
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Endodeoxyribonucleases
Eye
Female
Gene Expression Regulation, Developmental
Gene Silencing
Genes, Lethal
Male
Phenotype
RNA Interference
RNA, Double-Stranded

Source

Open in PubMed Open full text

Identifiers

PMID: 15514059
DOI: 10.1534/genetics.103.025965
PMCID: PMC1448832

Genes

DDB1
DDB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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