Article
Drosophila damaged DNA-binding protein 1 is an essential factor for development.
Genetics - 1 Oct 2004
Takata Kei-ichi, Yoshida Hideki, Yamaguchi Masamitsu, Sakaguchi Kengo
Abstract excerpt
The damaged DNA-binding protein (DDB) complex, thought to recognize (6-4) photoproducts and other lesions in DNA, has been implicated to have a role in global genomic nucleotide excision repair (NER) and E2F-1-mediated transcription. The complex consists of a heterodimer of p127 (DDB1) and p48 (DDB2), the latter also being known as XPE. We reported previously that in Drosophila expression of the DDB1 (D-DDB1)...
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