Article
Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.
PLoS genetics - 1 Oct 2011
Andersen Sabrina L, Kuo H Kenny, Savukoski Daniel, Brodsky Michael H, Sekelsky Jeff
Abstract excerpt
DNA repair mechanisms in mitotically proliferating cells avoid generating crossovers, which can contribute to genome instability. Most models for the production of crossovers involve an intermediate with one or more four-stranded Holliday junctions (HJs), which are resolved into duplex molecules through cleavage by specialized endonucleases. In vitro studies have implicated three nuclear enzymes in HJ resolution:...
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