Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila.

Genetics - 1 May 2000

Büchner K, Roth P, Schotta G, Krauss V, Saumweber H, Reuter G, Dorn R

Abstract excerpt

mod(mdg4), also known as E(var)3-93D, is involved in a variety of processes, such as gene silencing in position effect variegation (PEV), the control of gypsy insulator sequences, regulation of homeotic gene expression, and programmed cell death. We have isolated a large number of mod(mdg4) cDNAs, representing 21 different isoforms generated by alternative splicing. The deduced proteins are characterized by a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Consensus Sequence
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oogenesis

Share to Protein Isoforms

Share to Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 10790390
DOI: 10.1093/genetics/155.1.141
PMCID: PMC1461079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila.PMID 10790390Read ↗

The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.Semantic proximity Read ↗

Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila.Semantic proximity Read ↗

Mod(mdg4) variants repress telomeric retrotransposon <i>HeT-A</i> by blocking subtelomeric enhancersSemantic proximity Read ↗

Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.Semantic proximity Read ↗

Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis.Semantic proximity Read ↗

pitkin(D), a novel gain-of-function enhancer of position-effect variegation, affects chromatin regulation during oogenesis and early embryogenesis in Drosophila.Semantic proximity Read ↗

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.Semantic proximity Read ↗

Modifier of rudimentary p1, mod(r)p1, a trans-acting regulatory mutation of rudimentary.Semantic proximity Read ↗

Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins.Semantic proximity Read ↗

A high proportion of genes involved in position effect variegation also affect chromosome inheritance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.