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Article

RNA helicase Belle (DDX3) is essential for male germline stem cell maintenance and division in Drosophila.

Biochimica et biophysica acta - 1 Jun 2016

Kotov Alexei A, Olenkina Oxana M, Kibanov Mikhail V, Olenina Ludmila V

Abstract excerpt

The present study showed that RNA helicase Belle (DDX3) was required intrinsically for mitotic progression and survival of germline stem cells (GSCs) and spermatogonial cells in the Drosophila melanogaster testes. We found that deficiency of Belle in the male germline resulted in a strong germ cell loss phenotype. Early germ cells are lost through cell death, whereas somatic hub and cyst cell populations are...

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Identifiers

PMID: 26876306
DOI: 10.1016/j.bbamcr.2016.02.006

Genes

GSC

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