Article
piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline.
The Journal of cell biology - 10 Aug 2009
Lim Ai Khim, Tao Liheng, Kai Toshie
Abstract excerpt
Nuage, a well-conserved perinuclear organelle found in germline cells, is thought to mediate retroelement repression in Drosophila melanogaster by regulating the production of Piwi-interacting RNAs (piRNAs). In this study, we present evidence that the nuage-piRNA pathway components can be found in cytoplasmic foci that also contain retroelement transcripts, antisense piRNAs, and proteins involved in messenger RNA...
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