Article
Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types.
Nature genetics - 1 Mar 2026
Everall Andrew, Tapinos Avraam, Hawari Aliah, Cornish Alex J, Sud Amit, Chubb Daniel, Kinnersley Ben, Frangou Anna, Barquin Miguel, Jung Josephine, Church David N, Alexandrov Ludmil B, Houlston Richard S, Gruber Andreas J, Wedge David C
Abstract excerpt
Whole-genome sequencing (WGS) enables exploration of the full spectrum of oncogenic processes that generate characteristic patterns of mutations. Mutational signatures provide clues to tumor etiology and highlight potentially targetable pathway defects. Here alongside single-base substitution, doublet-base substitution, small insertion and deletion and copy number aberration signatures previously covered by the...
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