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Article

MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2010

George Julie, Kubarenko Andriy V, Rautanen Anna, Mills Tara C, Colak Elif, Kempf Tore, Hill Adrian V S, Nieters Alexandra, Weber Alexander N R

Abstract excerpt

Signals elicited by TLRs following the detection of microbes are integrated and diversified by a group of four cytoplasmic adaptor molecules featuring an evolutionarily conserved Toll/IL-1R signaling domain. Single nucleotide polymorphisms (SNPs) in TLRs and their adaptor molecules have been show...

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Source

Identifiers

PMID: 20164415
DOI: 10.4049/jimmunol.0901156

Genes

TIRAP
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20164415-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.PMID 20164415Read ↗

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Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.Semantic proximity Read ↗

Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.Semantic proximity Read ↗

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Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.Semantic proximity Read ↗

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).Semantic proximity Read ↗

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